Does premenstrual syndrome before pregnancy increase the risk of postpartum depression? Findings from the Australian Longitudinal Study on Women's Health

Previous literature suggests a positive association between history of premenstrual syndrome (PMS) and development postpartum depression (PPD); however, limited evidence has come from prospective population-based studies whether affects this is unknown. This study included 5479 women the 1973-78 cohort Australian Longitudinal Study on Women's Health estimated pre-pregnancy PMS PPD. Participants were followed 22-27 years in 2000 to 37-42 2015. was collected 4-category Likert-scale reporting frequency last 12 months (never, rarely, sometimes, or often) at survey preceding an index birth. PPD ascertained reports doctor diagnoses for each Relative risks (RRs) 95% confidence intervals (CIs) used estimate interest. The role assessed by testing its interaction with PMS. During 15 years’ follow-up, 15.4% participating reported PPD; 55.1% (rarely: 17.2%, sometimes: 25.7%, often: 12.2%). Compared who had no before pregnancy, those rarely similar risk (1.03, 0.82-1.30); whereas sometimes often significantly higher (1.31, 1.09-1.57 1.51, 1.22-1.87, respectively). History did not affect association. self-reported. severity collected. large provides dose-response relationship prior pregnancy PPD, independent depression. Evidence date potential help identify increased pregnancy.